Investigation and modeling of mechanical and surface-induced stress of pelleted filamentous microorganisms

For filamentous microorganisms the morphology and the productivity are closely linked. The productivity can be influenced by different cultivation parameters, for example the pH-value, media composition, media additives, mechanical stress and the concentration of the inoculum. This project deals with the investigation of the effects on morphology and therefore on the productivity caused by addition of micro- (< 30 µm) and macro- (up to 5 mm) particles during the cultivation of Lechevalieria aerocolonigenes. Early results showed an increased concentration of the antibiotic product Rebeccamycin for both particle size ranges. Two reasons seem to be responsible for the increased productivity: physicochemical surface effects caused by the addition of microparticles and mechanical stress due to the addition of macroparticles to the cultivation medium. Through the combination of experiments and simulations (coupling of CFD-DEM-simulations) the mechanisms of disaggregation of the bioagglomerates as well as the fragmentation of the mycelia are investigated. The results should lead to a stress energy model, which is able to predict the mechanical stress caused by the macroparticles.

responsible institutes:

Institut für Partikeltechnik
Volkmaroder Str. 5
38104 Braunschweig
Institut für Bioverfahrenstechnik
Rebenring 56
38106 Braunschweig
position name e-mail phone
Project supervisor Prof. Rainer Krull r.krull@tu-bs.de +49(0)531-39155311
Project employee Kathrin Pommerehne k.pommerehne@tu-bs.de +49(0)531-3918329
Project supervisor Prof. Arno Kwade a.kwade@tu-bs.de +49(0)531-3919610
Project employee Marcel Schrader marcel.schrader@tu-bs.de +49(0)531-39165533

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